N-ALPHA-T-BUTOXYCARBONYL-1-AMINO-CYCLOHEXANECARBOXYLIC ACID

Name	1-TERT-BUTOXYCARBONYLAMINO-CYCLOHEXANECARBOXYLIC ACID
Synonyms	RARECHEM EM WB 0029 N-BOC-AMINOCYCLOHEXYLCARBOXYLIC ACID 1-(BOC-AMINO)CYCLOHEXANECARBOXYLIC ACID BOC-1-AMINOCYCLOHEXANE-1-CARBOXYLIC ACID 1-BOC-AMINO-CYCLOHEXANE-1-CARBOXYLIC ACID N-ALPHA-T-BOC-1-AMINOCYCLOHEXANE CARBOXYLIC ACID 1-TERT-BUTOXYCARBONYLAMINO-CYCLOHEXANECARBOXYLIC ACID N-ALPHA-T-BUTOXYCARBONYL-1-AMINO-CYCLOHEXANECARBOXYLIC ACID 1-{[(tert-butoxy)carbonyl]amino}cyclohexane-1-carboxylic acid
CAS	115951-16-1
InChI	InChI=1/C12H21NO4/c1-11(2,3)17-10(16)13-12(9(14)15)7-5-4-6-8-12/h4-8H2,1-3H3,(H,13,16)(H,14,15)

Molecular Formula	C12H21NO4
Molar Mass	243.3
Density	1.13g/cm³
Melting Point	176-178°C (dec.)
Boling Point	391.2°C at 760 mmHg
Flash Point	190.4°C
Vapor Presure	3.3E-07mmHg at 25°C
BRN	4189683
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.496
Physical and Chemical Properties	Storage Conditions: Store at 0 ℃ WGK Germany:3

preparation	1-tert-butoxycarbonylamide cyclohexanecarboxylic acid was prepared as follows: A round-bottom flask was charged with sodium hydroxide solution (43ml, 4mol/L), THF(40ml), and 1-aminocyclohexanoic acid (5.0g,34.96mmol), di-tert-butyl dicarbonate (9.13g,41.96mmol) was added to the reaction flask. After completion of the dropwise addition, the reaction system was stirred at room temperature overnight. Water (100ml) was added to the reaction system, acidified with hydrochloric acid (50ml, 1mol/L), then extracted with ethyl acetate (50ml × 2), and the organic phases were combined, the organic phase was washed with saturated brine (100ml × 2) and dried over anhydrous sodium sulfate. The crude product was purified by silica gel column chromatography (petroleum ether/ethyl acetate (V/V)= 4/1), the title compound 1-t-butoxycarbonylamide cyclohexanecarboxylic acid was obtained as a white solid (7.3g,86%).
Application	1-tert-butoxycarbonylamide cyclohexanecarboxylic acid is useful as an intermediate in the synthesis of pharmaceuticals.
hazard management	if inhaling 1-tert-butoxycarbonylamide cyclohexanecarboxylic acid, move the patient to fresh air; if the skin is in contact, take off the contaminated clothing and rinse the skin thoroughly with soap and water. If you feel uncomfortable, seek medical advice, and immediately see a doctor; If you eat, immediately gargle, prohibit emetic, should immediately see a doctor.

Last Update：2024-04-09 21:50:46

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Product Name: 1-(Boc-amino)cyclohexanecarboxylic acid Visit Supplier Webpage Request for quotation
CAS: 115951-16-1
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Mobile: 18021002903
QQ: 3008007409

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